Titanium Turnpike

The Titanium Turnpike appears to suffer many of the same ills as its Earthly counterparts: tolls, huge traffic-snarling accidents, and armornecking motorists making things worse. The toll gates, however, are a lot more proactive than those on Earth; they are capable of snaring travelers who fail to pay their fine.

One of the city-states it passes by is Polyhex.

Marvel Comics continuity
The Titanium Turnpike was the stage for a Decepticon attack on Getaway's patrol, somewhere in early Cybertronian history. The Decepticons staged an accident to tie up traffic, then ambushed the patrol while they were stalled. Getaway led the damaged patrol through the highway's toll gates, which snagged the Decepticons when they attempted to pass through without paying, allowing the damaged Autobots to escape.

The battle became known as the famous Armornecking Incident.

Exodus
The Turnpike heaved and twisted, resembling a roller coaster, after Trypticon crashed into the Mithril Sea.